Genomic data

In a number of additional projects, genomic data has been collected in a subset of the Lifelines cohort population.

Genomic data

To facilitate research on healthy ageing, genomic data is very relevant. We have collected and analysed SNP data, gut microbiome data and whole genome sequence data. Currently available via Lifelines are SNP data collected with a genotyping array. This SNP dataset is called GWAS (Genome Wide Association Study). Other datasets are either available through a collaborating partner or data collection is still ongoing. For a specific request and to learn about the possibilities, please feel free to contact us.

GWAS

Genome-wide genotype data was collected using the Illumina CytoSNP-12v2 array. Currently SNP data from this array are available for ~15,000 participants. All GWAS participants are independent adults (18 years and older) and have Caucasian ancestry. The CytoSNP-12v2 array contains approximately 200,000 SNPs targeting regions. SNP data obtained from the array were used to map against human reference genomes, i.e. the Genome of The Netherlands (GoNL) release 5 and the 1000 Genomes phase1 v3 reference panels to impute more SNPs.  

How to apply for genomic data

If your application (also) concerned genotype data, you will have access to this data via a secure link to a High-Performance Computing (HPC) cluster from the Workspace. The cluster is equipped with the common programs for genotype data analysis. Read more about using the HPC cluster (download).