Generalizability of Predicting Disease Status Across Diverse Cohorts in IBD

Access to EGA study: EGAS00001001704 / Lifelines-DEEP

Please briefly describe your study aim and plan in no more than 4000 characters. Include:   A. outline of the study design and methodology;    B. proposed use of the requested data;    C. timeline;
- Outline/Methodology: This study will gather publicly available metagenomic studies for IBD  patients and healthy controls. Metagenomes will be assembled and taxonomy assigned using the CZID.org IDseq pipeline. Models trained on species relative abundances will predict disease  status. 
- Proposal: Combine European IBD cohorts with diverse geographic IBD cohorts to assess generalizability of predictive models. 
- Timeline: 3-6 months.