Phenotype-wide association analysis (PheWas) of established genetic risk loci of common diseases and traits

We aim to study if the genetic risk scores of common diseases and traits in general population are linked with other phenotypes, by using both the genetic and extensive phenotype data available in the Lifelines cohort. We aim to use this information to improve prediction of PRS at follow-up visits. We will create the genetic risk score per diseases of interest, based on the publically available dataset and internal research initiatives ongoing in the department of genetics. We will next calculate the genetic risk score for each participant of the Lifelines cohort, for whom the genotyping have been performed,  and perform the PheWAS to investigate if the genetic risk score of each disease is linked to blood metabolic and immune parameters, diseases, diet preferences, individual habits, and other phenotypes. Finally, we will use this information to improve prediction power of PRS at follow-up visits.