Probing interactions between host genetic predisposition, food intake, and the gut microbiome

Recent genomic studies have linked diet-related gene variants to metabolic disorders, like obesity and heart issues. These genetic variations are not only tied to dietary intake but have also been associated with gut microbial features that may influence health outcomes. However, previous studies that highlight these associations are limited in their ability to provide deep microbial taxonomic and functional profiling, as well as dietary specificity associated with health outcomes. To address these questions, our research aims to shed light on the complex interplay of genes, diet, and the microbiome in shaping cardiometabolic risks by analyzing comprehensive data from pooled large-scale human cohorts.