Shared and distinct mechanisms between mental disorders and noncommunicable chronic diseases: prevention, risk prediction and precision treatment

Mental disorders have been demonstrated to be associated with many noncommunicable chronic diseases, but causal relationships were not identified. By using the large datasets from Lifelines, we aim to: first, identify the associations between multiple mental disorders and noncommunicable chronic diseases in the observational study, and confirm the causal relationships using the Mendelian randomization approach; second, by integrating multi-omics data, we aim to identify shared and distinct genes, and biomarkers related to the comorbidities of multiple mental disorders and non-communicable chronic diseases.